Information about "GUTS, a comprehensive guide"
This page contains information
about the e-book on GUTS
entitled: "Modelling survival under chemical stress. A
comprehensive guide to the GUTS framework." The first
version was released on 18 January 2018. This book is
co-written by Tjalling
Jager and Roman
Ashauer, as part of a CEFIC-LRI
funded project. The book contains a detailed
description of GUTS (both conceptual and mathematical), its
special cases, and the associated statistics. Case studies
will be included to illustrate how to use GUTS on actual
data sets, and much, much more.
The book is offered through the Leanpub publishing
framework. As with the other e-books,
you have the opportunity to download it for free, but you
also have the option to pay for it. Please consider this
option, for it will allow us to dedicate time and effort to
updating this e-book, and writing new ones. In any case, it
is good to download this e-book from Leanpub yoursefl, as
you will be informed automatically when we release a new
You can download the e-book from this landing page at
Leanpub (Version 1.0 of 18 January 2018) or check out the
first 12 pages here.
Check the version/error
log for changes relative to the previous version, and
known errors in the current version.
Check out the list of survival papers over here. At this moment,
the list only contains papers using the hazard formulation
(i.e., GUTS-SD, GUTS-RED-SD, and its predecessors).
How do I refer to the book?
Please refer to the Leanpub page
with the version of the PDF. E.g.:
As general reference to GUTS, you can use the paper in the
- Jager T and Ashauer R (2018). Modelling survival under
chemical stress. A comprehensive guide to the GUTS
framework. Version 1.0. Toxicodynamics Ltd., York, UK.
Available from Leanpub: https://leanpub.com/guts_book.
- Jager T, Albert C, Preuss TG and Ashauer R (2011).
General Unified Threshold model of Survival - a
toxicokinetic-toxicodynamic framework for ecotoxicology.
Environ Sci Technol 45:2529-2540. http://dx.doi.org/10.1021/es103092a
Where can I find software to do 'GUTS' analyses?
Matlab-based software packages are offered on the BYOM pages. All GUTS cases can be
run. Links to other freely-downloadable software (such as
two R-packages for GUTS) is collected over here. In the book, we also
present the results from a ring test with 11 software
implementations. Not all of them are available yet, but for
many a freely-downloadable version is anticipated.
Ring test information
Data sets used for the GUTS ring test (as presented in
Chapter 7 of the e-book) can be downloaded
here as Excel file.
A detailed listing of the parameter estimates and
predictions (with confidence intervals) for the BYOM analyses has been collected into
a report. Download